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Enzymatic variability in Aedes aegypti (Diptera: Culicidae) populations from Manaus-AM, Brazil Genet. Mol. Biol.
Fraga,Elmary da Costa; Santos,Joselita Maria Mendes dos; Maia,Juracy de Freitas.
Eighteen enzymatic loci were analysed in Aedes aegypti populations from four neighbourhoods in the city of Manaus. The analyses showed that the Downtown population was the most polymorphic (p = 55.6%) with higher observed and expected mean heterozygosities (Ho = 0.152 ± 0.052; He = 0.174 ± 0.052, respectively). The least variability was detected in the Coroado and Cidade Nova populations, both with polymorphism of 44.4%. The latter population presented the least observed heterozygosity (Ho = 0.109 ± 0.037). Wright's F statistics showed that the mean value of Fis was higher than that of Fst (Fis = 0.164 > Fst = 0.048), and from analysis of molecular variance (AMOVA) it was found that 95.12% of the variability is found within populations indicating a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aedes aegypti; Electrophoreses; Isozymes; Populations genetics.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200011
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Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes Genet. Mol. Biol.
Santos,Ney Pereira Carneiro dos; Ribeiro-dos-Santos,Ândrea KC; Santos,Sidney EB.
Human serum paraoxonase (PON1) is an esterase associated with high density lipoproteins (HDLs) in the plasma and may confer protection against coronary artery disease. Serum PON1 levels and activity vary widely among individuals and populations of different ethnic groups, such variations appearing to be related to two coding region polymorphisms (L55M and Q192R). Several independent studies have indicated that the polymorphism at codon 192 (the R form) is a significant risk factor for cardiovascular disease in some populations, although this association has not been confirmed in other populations. Given the possible associations of these mutations with heart diseases and the fact that little or nothing is known of their prevalence in Amerindian...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Human serum paraoxonase; Populations genetics; Amerindian; PON1; Amazonian populations.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100006
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